The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes
نویسندگان
چکیده
Background and Aims: Diabetes mellitus is characterized by hyperglycemia which over time leads to serious damage of several body systems. Vanadium ions their complexes have been demonstrated various insulin-mimetic antidiabetic effects. The object the present work was investigate effect vanadyl sulfate (VS) on serum total lipid protein parameters, glutathione, peroxidation nonenzymatic glycosylation levels in cardiac, lens, lung skeletal muscle tissues STZ diabetic rats. Methods: Randomly selected 6.0 - 6.5 month old Swiss Albino rats were separated into two control groups. A single intraperitoneal injection 65 mg/kg streptozotocin (STZ) 0.01 M citrate buffer (pH 4.5) used induce diabetes. 100 VS administered daily one controls On 60th day experiment, determined. Results: Tissue samples taken for determination glutathione (GSH), (LPO) nonenzymatic (GSH) levels. Conclusion: According results, treatment with reversed effects diabetes exerting antioxidant properties preventing caused along some parameters.
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ژورنال
عنوان ژورنال: Istanbul university journal of pharmacy
سال: 2021
ISSN: ['2548-0731', '2587-2087']
DOI: https://doi.org/10.26650/istanbuljpharm.2020.0107